Amphetamine: Uses, side effects, and contraindications

Addiction is defined as the preoccupation with the acquisition and compulsive usage of a drug in spite of adverse consequences, with a history of relapse, and without regard to return of adverse effects and consequences (33). Impaired concentration and attention, impaired control of use, physical and mental manifestation of dependence, mood changes, anxiety, social problems, and risky use or behavior are potential adverse effects of amphetamine use and misuse (34, 35). It is important to note that some adverse effects of amphetamine use are also symptoms of ADHD. Amphetamine/dextroamphetamine may increase your heart rate or blood pressure. Keep all appointments with your health care provider to check your blood pressure and heart rate before starting amphetamine/dextroamphetamine and during treatment. If you measure your blood pressure and the top number (systolic) is 180 mm Hg or higher or the bottom number (diastolic) is 120 mm Hg or higher, get medical attention right away.

What are the symptoms of amphetamine dependence?

• Your doctor may check your blood pressure and heart rate regularly during treatment with this drug.
• Tell your health care provider if you have any of these side effects that bother you.
• Efforts to combat amphetamine addiction must take into account the unique challenges faced by different demographics.
• If you need to dispose of unused or expired amphetamine/dextroamphetamine, bring it to a medicine take-back program at an authorized collection site, such as a pharmacy or police station.

People who already have a mental health condition, such as bipolar Amphetamine Addiction disorder, may be at a higher risk of these side effects. Tell your health care provider right away if you have any of the following symptoms or if you have been told by others you have these symptoms. Recovery from amphetamine addiction is possible with the right support and treatment. It often involves a combination of therapy, medication-assisted treatment, support groups, and lifestyle changes.

Warnings for people with certain health conditions

While amphetamines have a high potential for addiction, the prescribed compulsive and addictive use Alcoholics Anonymous of amphetamines can be in perfect legal compliance, although it is accompanied by severe adverse consequences. It is important to note that there is a significant lack of longitudinal studies regarding long-term efficacy or addiction in the area of prescription stimulants. Some of the most common symptoms of ADHD include difficulty sustaining mental effort or cognitivity, impulsivity, alertness, fidgetiness, restlessness, inattention, and hyperactivity (1).

• Amphetamine may slow children’s growth or weight gain.Your child’s doctor will watch his or her growth carefully.Talk to your child’s doctor if you have concerns about your child’s growth or weight gain while he or she is taking this medication.
• Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
• From these results, it can be concluded that although in terms of d-amphetamine base equivalents lisdexamfetamine is clearly less potent than IR d-amphetamine, it does nonetheless produce d-amphetamine-like subjective effects in man.
• In October 2022, the FDA announced shortages of some amphetamine medications, especially drugs containing amphetamine, dextroamphetamine and lisdexamfetamine.

Seizure drugs

It is crucial for individuals struggling with amphetamine addiction to seek professional help and surround themselves with a strong support system to increase their chances of successful recovery. As shown in Figure 1, the similarity between the chemical structures of the catecholamine neurotransmitters, noradrenaline and dopamine, and the isomers of amphetamine is abundantly clear. The 3-D structures of the catecholamines and amphetamine molecules reveal the long planar conformation that is common to all of these compounds.

Implications of pharmacokinetics of lisdexamfetamine for efficacy, safety and recreational abuse liability

In vitro experiments revealed that the metabolism of lisdexamfetamine to d-amphetamine occurs in red blood cells by rate-limited enzymatic hydrolysis (Pennick, 2010). The effects of administration of d-amphetamine and lisdexamfetamine on the extracellular concentration of dopamine in the striatum and locomotor activity of freely moving rats. Different mechanisms leading to a 50% reduction in monoamine reuptake produced by a classical reuptake inhibitor versus a competitive substrate (releasing agent). Although racemic α-methylphenethylamine (amphetamine) was discovered by Barger and Dale in 1910, it was not until 1927 that this molecule was first synthesised by the chemist, G. A. Alles, whilst he was searching for a less costly and more easily synthesised substitute for ephedrine. Experiments performed in animals and human subjects by Alles and others unequivocally revealed α-methylphenethylamine’s ability to reverse drug-induced anaesthesia and produce arousal and insomnia (see reviews by Bett, 1946; Guttmann and Sargent, 1937).

What is amphetamine/dextroamphetamine used for?

While less common, the most serious side effects of amphetamine/dextroamphetamine are described below, along with what https://www.asocialmediaagency.in/what-does-it-mean-when-someone-says-i-relapsed/ to do if they happen. Additionally, behavioral therapy techniques, such as cognitive-behavioral therapy (CBT), can help individuals identify and modify the thought patterns and behaviors that contribute to their addiction. Amphetamine addiction is a complex issue that has far-reaching consequences for individuals and communities worldwide. It is a problem that knows no borders, affecting millions of people from all walks of life. To truly grasp the magnitude of this issue, it is important to examine global statistics and understand the demographics most affected.